Neutrophils are the chief cells during acute inflammation. Neutrophils release DNA filaments to form extracellular lattices known as neutrophil extracellular traps (NETs). NETs were first described in 2004 as a measure to trap and kill bacteria during infection. Today, NETs are fundamentally integrated infectious or sterile inflammatory conditions. We investigate how NET control the progression and outcome of acute inflammation.
We are investigating the role of role of extracellular DNA in liver regeneration and carcinogenesis. The project is embedded in the Collaborative Research Centre 841 “Liver inflammation: infection, immune regulation and consequences”.
Thromboembolic and cardiovascular disease
We use Neutrophil Extracellular Traps as a target to develop novel diagnostic assays and therapies for cardiovascular and thromboembolic diseases. The projects are supported in part by a Marie Curie International Incoming Fellowship to Tobias Fuchs, by a PhD student fellowship to Chandini Rangaswamy from the German Academic Exchange Service (DAAD) and by start-up funding from the Foundation for Pathobiochemistry and Molecular Diagnostics of the German Society for Clinical Chemistry and Laboratory Medicine (DGKL).